Faculty

Jeannine Marie Durdik

Jeannine Marie Durdik

Associate Dean of Natural Sciences

Professor of Biological Sciences

J. William Fulbright College of Arts & Sciences

(ARSC)-Arts & Sciences

Phone: 479-575-3684

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We have shown that pentoxifylline given during the development of a primary responses enhances the memory responses of T cells. We are currently exploring the mechanism of its activities in lymphocytes. We are testing the hypothesis that double stranded breaks accumulate in the DNA in older individuals and that this affects the development of lymphocytes in aged animals.

Molecular immunology, stability of genes, control of avian and mammalian immune responses.

Ph.D., Johns Hopkins University

Effects of delayed delivery of dexamethasone-21-phosphate via subcutaneous microdialysis implants on macrophage activation in rats.

Keeler GD, Durdik JM, Stenken JA.

Acta Biomater. 2015 Sep;23:27-37. doi: 10.1016/j.actbio.2015.05.011. Epub 2015 May 15.

PMID: 25985913

Peripheral residence of naïve CD4 T cells induces MHC class II-dependent alterations in phenotype and function.

Rane S, Das R, Ranganathan V, Prabhu S, Das A, Mattoo H, Durdik JM, George A, Rath S, Bal V.

BMC Biol. 2014 Dec 21;12:106. doi: 10.1186/s12915-014-0106-0.

PMID:

25528158

Free PMC Article

Localized delivery of dexamethasone-21-phosphate via microdialysis implants in rat induces M(GC) macrophage polarization and alters CCL2 concentrations.

Keeler GD, Durdik JM, Stenken JA.

Acta Biomater. 2015 Jan;12:11-20. doi: 10.1016/j.actbio.2014.10.022. Epub 2014 Oct 25.

PMID: 25449921

Free PMC Article

Role of apoptosis-inducing factor (Aif) in the T cell lineage.

Prabhu SB, Khalsa JK, Banerjee H, Das A, Srivastava S, Mattoo HR, Thyagarajan K, Tanwar S, Das DS, Majumdar SS, George A, Bal V, Durdik JM, Rath S.

Indian J Med Res. 2013 Nov;138(5):577-90. Review.

PMID: 24434313

Free PMC Article

Comparison of microdialysis sampling perfusion fluid components on the foreign body reaction in rat subcutaneous tissue.

Keeler GD, Durdik JM, Stenken JA.

Eur J Pharm Sci. 2014 Jun 16;57:60-7. doi: 10.1016/j.ejps.2013.11.005. Epub 2013 Nov 15.

PMID: 24239995

Free PMC Article

A role for apoptosis-inducing factor in T cell development.

Banerjee H, Das A, Srivastava S, Mattoo HR, Thyagarajan K, Khalsa JK, Tanwar S, Das DS, Majumdar SS, George A, Bal V, Durdik JM, Rath S.

J Exp Med. 2012 Aug 27;209(9):1641-53. doi: 10.1084/jem.20110306. Epub 2012 Aug 6.

PMID: 22869892

Free PMC Article

 

Hesse JE, Faulkner MF, Durdik JM.  Increase in double-stranded DNA break-related foci in early-stage thymocytes of aged mice. Exp Gerontol. 2009. 44(10):676-84. Epub 2009 Jul 12. [PubMed - in process]

Mattoo H., Kandpal U., Lewis V., Williams M., George A., Rath S,. Durdik J., Bal V. 2009. Naive T cells from aged mice progress poorly to the central memory stage and show increased susceptibility to death upon primary activation. 21(11):1277-89. Epub 2009 Sep 11.

Srivastava S., Banerjee H., Chaudhry A., Khare A., Apurva Sarin A., George A., Bal V., Durdik J. M., Rath S. 2007. Apoptosis-inducing factor (Aif) regulates death in peripheral T cells. J. Immunol. 179: 797-803.

Vig M., Srviastava S., Kandpal U., Sade H., Lewis V., Sarin A., George A., *Durdik J., *Bal V., *Rath S. 2004. Inducible nitric oxide synthase in T cells regulates T cell death and immune memory. [*communicating authors]. J. Clinical Investigation 113: 1734-1740.

Jena P. K., Smith D. A., Zhang X., Aviszus K., Durdik J. M., Wysocki, L. J.  2003. Somatic translocation and differential expression of lg Mu transgene copies implicate a role for the lgh locus in memory B cell development. Molecular Immunology 39:885-897.