Jeffrey A. Lewis

Jeffrey A. Lewis

Assistant Professor

J. William Fulbright College of Arts & Sciences

(BISC)-Biological Sciences

Phone: 479-575-7740

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All organisms must endure diverse environmental stresses during their lifetime. Our lab seeks to understand how cells adapt and even thrive in the face of various environmental assaults. Cellular stress responses are remarkably complex, coordinating multiple levels of sensing, signal transduction, and global regulatory networks. Thus, stress research feeds into nearly all aspects of cell biology, with implications for human disease, microbial pathogenesis, and the evolution of regulatory networks.

Our group is interested in both the function and regulation of stress defenses. On the functional level, we are interested in the coordination and logic of stress-responsive regulatory networks, and how stress defense genes allow cells to maintain homeostasis. We are also interested in how natural variation shapes differences in how individuals perceive and respond to stress. We frequently turn to nature to understand aspects of stress defense that are absent in laboratory strains. We are leveraging this approach to generate novel insights into  the regulatory logic and function of stress signaling and defense.

More details about our research group can be found on our lab website.

General Genetics, Biological Regulation and Subcellular Communication, Laboratory in Microbial Fermentation

Ph.D. University of Wisconsin, 2007

B.S. University of California, Santa Barbara, 2001