Michael Herbert Lehmann
J. William Fulbright College of Arts & Sciences
My laboratory studies the basic principles of animal development. In particular, we are interested to understand how hormonal and other signaling processes regulate and coordinate development, growth and metabolism. We use a model organism, the little fruit fly Drosophila melanogaster, to study developmental processes at an organismal level using an array of genetic and molecular tools that is unique for this organism. Since the basic mechanisms underlying development are conserved between flies and vertebrates including humans, we hope that the results of our research will be of general significance.
I teach an upper level class in Developmental Biology and contribute to the teaching of our core course in General Genetics.
Ph.D. Philipps University Marburg, 1988.
Schmitt, S., Ugrankar, R., Greene, S.E., Prajapati, M., Lehmann, M. (2015). Drosophila Lipin interacts with Insulin and TOR Signaling Pathways in the Control of Growth and Lipid Metabolism. J. Cell Sci. 128, 4395-4406.
Smith, K. G., and Lehmann, M. (2014). Friedrich Gerstäcker’s natural history observations in Arkansas 1838-1842. Arkansas Historical Quarterly, Vol. LXXIII, no 1, p. 17-30.
Ugrankar, R., Liu, Y., Provaznik, J., Schmitt, S., and Lehmann, M. (2011). Lipin is a Central Regulator of Adipose Tissue Development and Function in Drosophila melanogaster. Mol. Cell. Biol. 31, 1646-1656. PMCID: PMC3126333
Lehmann, M. (2008). Roles of the FOXA transcription factor Fork head in autophagic developmental cell death. Autophagy (Addendum) 4, 713-714.
Liu, Y. and Lehmann, M. (2008). A Genomic Response to the Yeast Transcription Factor GAL4 in Drosophila. Fly 2, 92-98. PMCID: PMC2803330
Liu, Y. and Lehmann, M. (2008). Genes and biological processes controlled by the Drosophila FOXA orthologue Fork head. Insect Mol. Biol. 17, 91-101.
Cao, C., Liu, Y., and Lehmann, M. 2007. Fork head controls the timing and tissue selectivity of steroid-induced developmental cell death. J. Cell Biology 176:843-852.
Liu, Y. and Lehmann, M. 2006. FOXO-independent suppression of programmed cell death by the PI3K/Akt signaling pathway in Drosophila. Dev. Genes Evol. 216, 531-535.
Lehmann, M. 2004. Anything else but GAGA: a nonhistone protein complex reshapes chromatin structure. Trends in Genetics 20:15-22.
Lehmann, M., Jiang, C., Ip, Y. T., and Thummel C. S. (2002). AP-1, but not NF-B, is required for efficient steroid-triggered salivary gland cell death in Drosophila. Cell Death Differ. 9, 581-590.
Schwendemann, A. and Lehmann, M. 2002. Pipsqueak and GAGA factor act in concert as partners at homeotic and many other loci. Proc. Natl Acad. Sci. USA 99:12883-12888.
Siegmund, T. and Lehmann, M. 2002. The Drosophila Pipsqueak protein defines a new family of helix-turn-helix DNA-binding proteins. Dev. Genes Evol. 212:152-157.
Renault, N., King-Jones, K., and Lehmann, M. (2001). Down-regulation of the tissue-specific transcription factor Fork head by Broad-Complex mediates a stage-specific hormone response. Development 128, 3729-3737.