Department Chair & Professor, Organic Chemistry
(ARSC)-Arts & Sciences
(CHBC)-Chemistry & Biochemistry
The McIntosh research group is involved in synthetic organic chemistry, including both synthetic methods development and total synthesis of complex natural products. Current targets include sclerophytin-A, massileunicellin-I and antascomicin-B.
Natural product total synthesis is the reconstruction of a naturally occurring compound in the laboratory starting from simple, commercially available materials. There are several goals of natural products total synthesis:
- Prove or disprove the proposed structure of the natural product
- Provide additional quantities of the natural product for biological testing
- Learn the unique chemistry of the natural product
- Modify the natural product to improve its biological profile, e.g. improve potency, decrease side effects, increase metabolic stability, increase solubility, etc.
- Discover new organic chemistry
In the course of our investigations, we have developed a number of new variants of organic reactions, including the Claisen rearrangement, the allylic diazene rearrangement, and the cycloaldol reaction. For more detailed information on these and other projects in the McIntosh group, visit the group home page (link below).
American Cancer Society Postdoctoral Fellow, Stanford University
Ph.D., The Pennsylvania State University
B.A., Virginia Tech