• Multi-dimensional NMR spectroscopy for use in protein structure determination as well as dynamics.
• Protein dynamics calculations to characterize intramolecular motions in proteins.
• Steady-state and Time-resolved Fluorescence Spectroscopy.
• Isothermal titration calorimetry.
• Differential Scanning Calorimetry
• Post column derivative-based amino acid analysis of peptides and proteins, protein expression and purification.
• Circular Dichroism Spectroscopy.
• Biochemical characterization of Protein-Protein Interactions (PPIs) and the influence of small molecule targets on PPIs.
Ph.D. Biophysical Chemistry, Case Western Reserve University
B.S. Biochemistry, Louisiana State University
Kyla M. Morris, Rory Henderson, Colin D. Heyes, TKS Kumar and Paul D. Adams, “A Switch I Mutant of Cdc42 Bound to an Effector Protein Influences Its Ability to Inhibit GTP Hydrolysis”, 2016, Small GTPases, 2016, Vol. 7, #1, 1-11.
Reena Chandreshekar and Paul D. Adams, “NMR Spectroscopy Provides a Novel Bioanalytical and Biophysical Approach Towards the Characterization of Protein Interactions Involved in the Integration of RAS Signaling”, 2015, Journal of Analytical and Bioanalytical Techniques, 6:5.
Srinivas Jayanthi, Jacqueline Morris, Beatrice Kachel, Musaab Al-Ameer, Rory Henderson, Paul D. Adams*, and Thallapuranam Krishnaswamy Suresh Kumar*, The Versatility of Isothermal Titration Calorimetry in Modern Biology, 2015, Journal of Analytical and Bioanalytical Techniques, Vo. 6, #3.
K. Kathir, D. Rajalingam, A. Daily, S. Jayanthi, R. Thurman, L. Rutherford, R. Chandrashekar, P. Adams, I. Prudovsky and TKS Kumar, “Copper binding affinity of the C2B domain of synaptotagmin -1 and its potential role in the nonclassical secretion of Acidic Fibroblast Growth Factor”, Biochimca et Biophysica Acta, 2014, #1844 p. 2155-2163.
Reena Chandrashekar and Paul D. Adams, “Prospective Development of Small Molecule Targets to Oncogenic Ras Proteins”, Open Journal of Biophysics, 2013, #4, p 207-211.
R. Chandrashekar, O. Salem, H. Krizova, R. McFeeters and P. D. Adams, “A switch 1 mutant of Ras protein Cdc42 exhibits decreased conformational freedom”, 2011, Biochemistry, 50(28):6196-207.
K. Kathir, L. Gao, D. Rajalingam, A. Daily, S. Brixey, H. Liu, D. Davis, P.D. Adams, I. Prudovsky, and T.K.S. Kumar, “NMR Characterization of the Copper and Lipid Interactions of the C2B Domain of Synaptotagmin I-Relevance to the Non Classical Secretion of the Human Acidic Fibroblast Growth Factor (hFGF-1)”, Biochim. Biophys. Acta, (2010), vol 1798, #2, p. 297-302.
D. Rajalingam, K. Kathir, K. Ananthamurthy, P.D. Adams, T.K.S. Kumar, “An Efficient Method to Prevent the Degradation of Recombinant Proteins by Thrombin,” Analytical Biochemistry, (2008), 375, p.361-363.
R.E. Oswald and P.D. Adams, “NMR Assignment of Cdc42(T35A), an Active Switch I Mutant of Cdc42,” Biomolecular NMR Assignments, (2007), 1: p. 225-227.
Robert C. and Sandra Connor Endowed Faculty Fellow, Fulbright College of Arts and Sciences 2007-2008
NSF Minority Postdoctoral Fellow, Cornell University 2002-2005
Postdoctoral Associate, Cornell University 2000-2002
National Institutes of Health (NIH)
National Cancer Institutes (NCI)
National Science Foundation (NSF)
Arkansas Biosciences Institutes (ABI)
Arkansas Science and Technology Authority (ASTA)