Faculty

David S. McNabb

David S. McNabb

Associate Professor

Department Chair

J. William Fulbright College of Arts & Sciences

(BISC)-Biological Sciences

Phone: 479-575-3787

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Development of antifungal compounds: A major focus of our laboratory involve collaborative projects with Dr. Suresh Kumar and Dr. Matt McIntosh in the Department of Chemistry and Biochemistry, and Dr. Ines Pinto in the Department of Biological Sciences to identify compounds or peptides that display antifungal activity for potential use in the treatment of fungal infections in humans.  In addition, we explore the mechanism(s) of action of these antifungal agents.

The role of the CCAAT-binding factor in Candida albicans pathogenesis.  The main focus of this research is to determine the role of the CCAAT-binding factor in Candida albicans pathogenesis.  In particular, we are interested in how this transcription factor regulates genes involved in iron uptake/utilization and genes involved in the oxidative stress response.

Understanding the impact of graphene-based nanomaterials on human health.  The main focus of this research is to evaluate the toxicity of various graphene-based nanomaterials to eukaryotic cells using Saccharomyces cerevisiae as model single-celled eukaryote.

Cell Biology, Infectious Disease, Infectious Disease Mechanisms, Human Viruses and Disease,

BIOL2533 Cell Biology; Fall semester each year

BIOL4753/5753; General Virology, Spring semester each year

Post-doctoral Massachusetts Institute of Technology, 1994

Post-doctoral Louisiana State University Medical School, 1993

Ph.D. Louisiana State University Medical School, 1992

B.S. University of Texas-Arlington, 1986

Chakravarti, A., K. Camp, D.S. McNabb, and I. Pinto. 2017. The iron-dependent regulation of the Candida albicans oxidative stress response by the CCAAT-binding factor. PLoS One:12 (1):e0170649 doi:10.1371/journal.pone.0170649

Mukherjee, R.P., S. Jayanthi, T.K.S. Kumar, D. McNabb, and R. Beitle. 2016. Production of an anti-Candida peptide via fed batch and ion exchange chromatography. Biotechnology Progress: 8:865-871

Morris, J., S. Jayanthi, R. Langston, A. Daily, A. Knight, D.S. McNabb, R. Henry, and T.K.S. Kumar. 2016.  Heparin-binding peptide as a novel affinity tag for purification of recombinant proteins.  Protein Expression and Purification: 126:93-103.

Hyun, C. H. Kaur, D. McNabb, and J. Li. 2015. Dielectrophoretic Stretching of DNA Tethered to a Fiber Tip. Nanotechnology 26: 25501

Uplinger, J, B. Thomas, R. Rollings, D. Fologea, D. McNabb, and J. Li. 2012. Effects of Metallic Ions K+, Na+, Mg2+, and Ca2+ on Free Translocation of DNA in Silicon Nitride Nanopores.  Electrophoresis 23:3448-3457.

Rollings, R.C., D.S. McNabb, and J. Li.  2012.  DNA characterization with Ion Beam-Sculpted Silicon Nitride Nanopores.  p. 79-97.  In Nanopore-based Technology: Single Molecule Characterization and DNA sequencing, In Gracheva M (ed), Methods in Molecular Biology, Humana Press, New York.

Blanchard, A., C. Wolter, D.S. McNabb, and E. Gross.  2010.  Wave-SOM: A novel wavelet-based clustering algorithm for analysis of gene expression patterns. IJKDB 1(2):50-71.